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Literature summary extracted from

  • Xue, P.; Zeng, F.; Duan, Q.; Xiao, J.; Liu, L.; Yuan, P.; Fan, L.; Sun, H.; Malyarenko, O.S.; Lu, H.; Xiu, R.; Liu, S.; Shao, C.; Zhang, J.; Yan, W.; Wang, Z.; Zheng, J.; Zhu, F.
    BCKDK of BCAA catabolism cross-talking with the MAPK pathway promotes tumorigenesis of colorectal cancer (2017), EBioMedicine, 20, 50-60 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.4 ATP + mitogen-activated protein kinase kinase Homo sapiens the enzyme promotes cell transformation or colorectal cancer by enhancing the MAPK signaling pathway through direct MEK phosphorylation ADP + phosphorylated mitogen-activated protein kinase kinase
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.4 Homo sapiens O13874
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.4 colonic cancer cell line the enzyme (BCKDK) is widely expressed in colorectal cancer patients, and patients that express higher levels of BCKDK have shorter survival times than those with lower levels Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.4 ATP + mitogen-activated protein kinase kinase the enzyme promotes cell transformation or colorectal cancer by enhancing the MAPK signaling pathway through direct MEK phosphorylation Homo sapiens ADP + phosphorylated mitogen-activated protein kinase kinase
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 ?
2.7.11.4 ATP + mitogen-activated protein kinase kinase phosphorylation of mitogen-activated protein kinase kinase (MEK) at Ser221 Homo sapiens ADP + phosphorylated mitogen-activated protein kinase kinase
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.4 BCKDK
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 Homo sapiens
2.7.11.4 branched-chain alpha-keto acid dehydrogenase kinase
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 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.11.4 physiological function rate-limiting enzyme in branched-chain amino acids catabolism Homo sapiens
2.7.11.4 physiological function rate-limiting enzyme in branched-chain amino acids catabolism, which plays an important role in many serious human diseases. The enzyme promotes cell transformation or colorectal cancer by enhancing the MAPK signaling pathway through direct mitogen-activated protein kinase kinase (MEK) phosphorylation, rather than by branched-chain amino acids catabolism Homo sapiens